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A 2023 systematic review and meta-analysis of 82 RCTs (10,332 patients) examined probiotics for IBS symptoms, and for abdominal bloating or distension reported only very low certainty in the evidence for a benefit, with some specific combination probiotics and Bacillus strains showing potential signals.[5] Certainty grading reflects how confident the analysis is in the effect estimate

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[1] [2] This low introductory dose is intentional it allows the body to gradually adapt to the drug's pharmacological effects before the dose is escalated

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