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MS alone is not generally described as a direct contraindication in incretin medication labeling
The multiple cardiometabolic benefits include improving glycemic control, lipid profiles, blood pressure, inflammation, and hepatic steatosis
Sarcopenia is also linked to an increased risk of chronic diseases, such as type 2 diabetes, cardiovascular disease, and certain types of cancer
The prescriber should review a complete medical history, including cardiovascular history, endocrine conditions, thyroid status, personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (the established contraindications for GLP-1 class drugs), and any psychiatric history relevant to appetite dysregulation or eating disorders
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