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Studies have demonstrated that GLP-1 receptor activation may reduce production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1) the same inflammatory mediators that drive joint destruction in rheumatoid arthritis

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Magnesium can enhance the formation of chondrocytes from synovial mesenchymal stem cells, promote chondrocyte proliferation and improve the effect of growth factor through continuous effects in the process of cartilage formation (77)