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GSH deficiency on hepatocyte epigenetic modifying enzymes Hepatocytes treated with GCLC siRNA showed elevated Dnmt, Tet2, and Tet3, but Tet1 was downregulated, and there was no change in Tdg mRNA expression (Fig
: DSIP
A large number of antioxidant based strategies focusing on ascorbic acid, deferoxamine, cucurmin etc has been investigated for management of the PD symptoms but without any translatable benefits 47,48
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