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Escitalopram, a selective serotonin reuptake inhibitor (SSRI) antidepressant, and Wegovy (semaglutide), a GLP-1 receptor agonist for weight management, work through entirely different mechanisms

Clinical trial results discussed in this article - STEP 1 (14.9% average body weight loss with semaglutide), SURMOUNT-1 (20.9% average body weight loss with tirzepatide), and SELECT (20% reduced risk of major cardiovascular events with FDA-approved Wegovy in a specific patient population) - relate to studied active ingredients and specific FDA-approved formulations in controlled trial populations and should not be interpreted as guaranteed outcomes for any individual patient or compounded formulation

Trends in weight regain following Roux-en-Y gastric bypass (RYGB) bariatric surgery