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Cystine enters cells through system Xc- and is reduced to cysteine via the thioredoxin reductase 1 (TXNRD1)-dependent pathway and then contributes to GSH production (Fig

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Depletion of GSH and therapeutic implications The depletion of GSH levels has been demonstrated in aging and multiple chronic degenerative diseases, including neurodegenerative, cardiovascular, pulmonary, immune disorders and cancers ( For this reason, many studies have been conducted on the best methods to increase intracellular and intramitochondrial levels of GSH

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