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Although epidemiologic studies have shown an association between vascular disease and hyperhomocysteinemia, large randomized controlled trials have shown that lowering homocysteine levels in these patients does not reduce the number of myocardial infarctions or strokes, or improve mortality rates
NNMT methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor
The lack of information is because of insufficient human clinical trials
Last clinically reviewed: 31 July 2026 Clinical information sources NICE NG239 Vitamin B12 deficiency in over 16s: diagnosis and management NHS Vitamin B12 or folate deficiency anaemia NHS Diagnosis NHS Treatment MHRA Vitamin B12 and cobalt allergy advice This page provides general information about the pharmacy service and does not replace personalised advice from a pharmacist, GP or other healthcare professional
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