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It decreases inflammation and helps to repair cellular damage
Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss
AOD-9604 produces modest weight loss (2-3 kg over 12 weeks in trials) through peripheral fat tissue activation without any appetite effects
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