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Donanemab reduced the tau burden in the temporal, parietal, and frontal lobes and significantly decreased plasma pTau217 by 24% in the treatment group, whereas the placebo group exhibited a 6% increase in plasma pTau217 at the end of the trial [49]

Tardif I, Gunette L, Zongo A, Demers , Lunghi C

A Timeline for Appetite Suppression The appetite-suppressing effects of semaglutide typically increase gradually over several months as the dosage is increased