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According to the American Diabetes Association, prediabetes can be defined by a condition of impaired fasting glucose, characterized by a fasting blood glucose concentration between 100 mg/dL and 125 mg/dL and/or a condition of impaired glucose tolerance, characterized by a 2-hour blood glucose concentration 140 mg/dL following an oral glucose tolerance test (56)

This part of the polypeptide chain is involved in different interdomain and intersubunit interactions especially with residues from the amino-terminal arm region from another subunit [30, 47]

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