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Moreover, these hormones contribute to beta cell proliferation and longevity, which is particularly relevant in type 2 diabetes where beta cell function is compromised

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447,448,449,450 Upregulated autophagy in macrophages enhances the production of pro-inflammatory cytokines such as IL-6 and TNF-, while autophagy deficiency promotes exaggerated inflammasome activation, as demonstrated by ATG16L1 ablation increasing IL-1 and IL-18 secretion

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