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The FDA and EMA have issued specific guidance to encourage sponsors from the medical industry to assess potential DDI [46, 47]
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Given that GCL or GGT pharmacological inhibition or silencing effectively blocks the growth of lymphoid tumor cells in 3D gels, including TIC-like cells, we propose that high glutathione levels in the minority of tumor cells that thrive in 3D gels counteract ROS-induced cell death
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