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demonstrated that GLP-1 RAs could alleviate cytoplasmic Ca 2+ overload in VSMCs in SHRs, improve the arterioles systolic and diastolic functions, and reduce BPV by upregulating Na + /Ca 2+ exchanger 1 (NCX1) expression via the Akt signaling pathway [80]
However, weight loss medications like Semaglutide work best when combined with lifestyle changes
Month 6-12 (2.4 mg maintenance): Weight loss continues but gradually slows
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