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Although these changes in HR upon GLP-1 RA administration were subtle and the underlying mechanisms are unclear, further studies are necessary to elucidate the long-term effects of GLP-1 RAs primarily on HR and other related variables to clarify whether the elevated HR can be regarded as a transient reflex mechanism or whether it might in fact lead to poor cardiovascular outcomes in a diabetic population
After blocking in 5% goat serum (Beyotime) for 30 min, the sections were incubated with antibodies against insulin, glucagon, fibronectin, desmin, and -SMA (Supplementary Table 2) at 4 C overnight
Second, they are most common during escalation periods and tend to decrease as the body adapts
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