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Probiotics play a crucial role in modulating prostaglandin E2 (PGE2), an anti-inflammatory prostanoid that inhibits the secretion of pro-inflammatory cytokines, such as IL-1 and TNF-, by macrophages (174)

Individuals at risk of AD or with diabetes may be in the early or middle biological stage of AD, offering a greater opportunity for GLP-1RAs to provide neuroprotection

All statistical analyses were performed using the GraphPad Prism 5.0 software (GraphPad Software Inc., San Diego, CA, USA) and SPSS 15.0 software (SPSS, Inc., Chicago, IL, USA)

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