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The STEP trials included participants up to age 75, and weight loss outcomes were significant across age groups
Pre-malignant states or family history of GH-responsive tumours would require specialist input
Almost all patients will have some gastrointestinal side effects during the first week or two of taking the medication, but those symptoms typically resolve over the first two to four weeks and are rarely severe enough to stop therapy
Moreover, these patients often exhibit unfavorable body composition, with approximately 10% greater fat mass at the expense of lean mass, as well as increased visceral adiposity compared to subjects without this condition.4 Patients with HS are also more likely to coexist with metabolic comorbidities, which are frequently suboptimally controlled
