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Am J Physiol Gastrointest Liver Physiol (2013) 304(11):G94957.10.1152/ajpgi.00493.2012 40 ArciszewskiMBEkbladE
Additionally, PAR2-dependent signaling has been implicated in promoting weight gain and metabolic inflammation in mouse models of diet-induced obesity (DIO) (23), but the specific proteases by which PAR2 signaling exerts metabolic inflammation and DIO remain unclear (24)
Tirzepatide's additional GIP pathway activation may contribute to a different side effect profile in some patients, though head-to-head comparisons show similar tolerability overall
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