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Compounded tirzepatide is a dual-action medication that targets hormones involved in regulating appetite and controlling blood sugar levels
Immediate steps for patients: Stop taking tirzepatide immediately and do not administer any further doses until medically reviewed Seek urgent medical attention by contacting NHS 111, attending an emergency department, or calling 999 if symptoms are severe Avoid eating or drinking if experiencing severe pain or vomiting until medically assessed Avoid alcohol completely if this is a contributing factor Clinical assessment and investigation: When patients present with suspected pancreatitis, healthcare professionals should conduct a thorough evaluation including: Detailed history : Characterisation of pain, associated symptoms, medication history (including tirzepatide dose and duration), alcohol intake, and previous pancreatic disease Physical examination : Assessment for epigastric tenderness, abdominal guarding, fever, tachycardia, and signs of systemic compromise Laboratory investigations : Serum lipase (preferred in UK practice for specificity) or amylase, full blood count, renal function, liver function tests, calcium, glucose, and lipid profile Imaging studies : Abdominal ultrasound to identify gallstones
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It notes tirzepatide carries FDA warnings for acute pancreatitis alongside medullary thyroid carcinoma and thyroid C-cell hyperplasia seen in animal studies
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