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It was highlighted that the excessive ROS production through activation of NADPH oxidase contributes to sensitization in DRG neuron for persistent pain induction (Kallenborn-Gerhardt et al., 2017) (Table 1)

206 At typical doses, pyridoxine is readily transported across cell membranes and converted to the active form of B 6 , pyridoxal 5-phosphate (P5P)

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Moreover, PorB activation of TLR2 has been demonstrated to enhance bacterial internalization, suggesting that the expression of different PorB variants may be another factor affecting meningococcal internalization (Toussi et al., 2016)