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This could revolutionize obesity treatment - but we need more long-term safety data before it becomes mainstream
Importantly, the ECD of GLP-1R undergoes a remarkable orientation change from the closed TMD-interacting conformation to the extended active conformation during peptide binding and activation
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Diabetes 60(12):31033109 Yanagimachi T, Fujita Y, Takeda Y et al (2016) Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (130) expression is upregulated in diabetes and PEGylated GIP(130) can suppress the progression of low-dose-STZ-induced hyperglycaemia in mice
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