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The differential diagnosis should include other melanotic lesions, such as malignant melanoma, pigmented meningioma, and medulloblastoma [ 5 ]
Nevertheless, these studies appear encouraging and more trials are underway. Although pain reduction remains important in OA, the big question and one representing a massive unmet need is whether the drugs can actually modify OA disease course
(ii) major medical problems, including cardiac, liver, endocrine, or renal disease
Gastrointestinal (GI) Nausea (most common, especially during the first few weeks)
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