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These findings suggest a dual role for iron in M1 macrophages: while endogenous iron sequestration may facilitate ferroptosis, excess extracellular iron may conversely suppress inflammatory activation
Some Phase 3 trial sites are in Asia (REDEFINE 5, REDEFINE 6) but no regulatory approvals have been announced as of June 2026
N Engl J Med, 384:989-1002
Monitorizacin de la afectacin heptica Las pruebas de funcin heptica deben formar parte de la monitorizacin rutinaria de los pacientes que reciben NP
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