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The STEP 1 clinical trial demonstrated average weight loss of approximately 15% of body weight over 68 weeks with semaglutide 2.4mg, but these results were achieved in conjunction with dietary counselling and a 500 kcal per day calorie deficit, as highlighted in NICE TA875
No cases of symptomatic hypoglycemia occurred in that trial, though glucose monitoring was not a primary endpoint and baseline metabolic data were not reported
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