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The origin of the ChaC nomenclature comes from the Escherichia coli ( E.coli ) ChaC gene which is the third identified gene in the Cha operon, an operon whose encoded proteins regulate the movement of calcium and sodium ions.
There was a lot of interest in obesity also in pharma, but they all wanted to make small molecules that would deeply penetrate the brain
The tradeoff is that low doses become harder to measure precisely
10.1016/j.cyto.2008.10.012 148
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