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Ozempic, Wegovy, Rybelsus, Mounjaro, and Zepbound also carry a boxed warning for the potential risk of thyroid C-cell tumors, including medullary thyroid carcinoma
The most common side effects are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, affecting up to 4050% of patients initially
In mice, TAS2R131 has been implicated in xenobiotic defense by promoting mucus production in the colon (80)
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