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Until patents expire and competition enters the market, it is likely that the prices of these medications will remain elevated.

Conversely, in another phase 2b study involving patients with T2DM, tirzepatide showed significantly better efficacy in glucose control and weight loss compared to both placebo and dulaglutide, with an acceptable safety and tolerability profile (111)

The core difference between the two lies in whether the negative feedback function of the HPA axis (sensitivity) is normal

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