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This gradual escalation strategy minimizes nausea and other adjustment side effects while building toward your therapeutic dose
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reported that LDH inhibition rewired IL-2-induced effector-like metabolism, promoted pyruvate entry into the TCA cycle and subsequent OXPHOS, and suppressed the expression of IL-21-induced exhaustion markers, enhancing the formation of stem cell memory T cells (T SCM ) and augmenting antitumor immune responses [296]
Chong B, Kong G, Shankar K, et al
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