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These challenges necessitate frequent dosing or the use of modified analogs and innovative delivery systems to sustain therapeutic concentrations
For instance, gene expression changes related to depression predominantly occur in microglia, which play a crucial role in the development of depression-like behaviors
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After a meaningful gap of several weeks or more, the tolerance your body built up during the original slow titration fades, so a clinician typically has you restart at a lower dose and titrate back up
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