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This is in contrast with the beneficial effects reported previously for the triagonist, in terms of reversion of adiposity excess and improved metabolic profile in diet-induced obese female mice 42 , suggesting that hyperandrogenism is bound to particular metabolic features that require specific multi-agonist treatments for maximum efficacy

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Furthermore, studies examining the diapedesis of HIV-1-infected monocytes across an in vitro BBB model have demonstrated increased Rho kinase-mediated phosphorylation of occludin and claudin-5, linking immune cell migration across the BBB to TJ alterations [192]

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