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Activation of NRF2/FPN1 pathway attenuates myocardial ischemia-reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis

First, it seemed to calm inflammation

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Mechanistically, sorafenib suppresses system Xc-, which promotes ER stress, GSH depletion, and the iron-dependent accumulation of lipid ROS (Sun et al., 2016b)