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Exclusion criteria comprised a history of previous bariatric surgery, contraindications to IGB insertion or semaglutide use, the presence of gastrointestinal disorders such as inflammatory bowel disease or gastroparesis, severe organ dysfunction (renal, hepatic, or cardiac), pregnancy, and current use of other anti-obesity medications
Concurrent medications may also play a role
1 and 2 reviewed the quality assessment of included studies
Anti-inflammatory and neuroprotective effects Not all of tirzepatide brain effects are potentially anxiety-provoking
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