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Eventually, GABA is removed from the system by converting it into succinate, which is then used in the Krebs cycle in the mitochondria to make ATP.[ref] The enzyme succinic semialdehyde dehydrogenase ( ALDH5A1 gene) is needed to convert GABA into succinate.[ref] Rare genetic mutations in the ALDH5A1 gene cause succinic semialdehyde dehydrogenase deficiency, which decreases the breakdown of GABA
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The NHS recommends adults aim for about 6-8 glasses of fluid daily (approximately 1.5-2 litres), though individual requirements vary based on body size, activity level, and climate
10: Gallwitz B (2019) Clinical Use of DPP-4 Inhibitors
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