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This study showed that GLP-1 receptor agonist use was associated with markedly diminished risks of cirrhosis (aHR: 0.72, 95%CI: 0.66-0.79) and HCC (aHR: 0.65, 95%CI: 0.56-0.76) compared to non-use throughout a mean observation period of 4.8 years, with benefits observed across different baseline liver disease stages [57]

Compounds binding there can stabilise the active conformation without needing to mimic the full peptide-extracellular-domain interaction

When administered the peptide, mice with moderate AD exhibited a reduced level of amyloid beta plaques in the brain, improved cognitive functionality and synaptic transmission, and protection against neuronal death