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Most people report that nausea improves as their body acclimates over several weeks

Protocol 1: Standard weight management Goal: Optimize fat loss while minimizing lean mass loss during tirzepatide therapy

These skeletal consequences are particularly concerning given the global rise in obesity, increased use of weight loss interventions, and the aging of the population

Risk-benefit analysis should consider the severity and impact of the condition being treated, failure or limitations of conventional therapies, individual patient risk factors particularly for malignancy, and patient preferences regarding experimental treatments