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The supplemented group showed decreased respiratory quotient, increased fat oxidation percentage, reduced insulin levels, improved insulin sensitivity (HOMA index), reduced waist circumference, and increased resting energy expenditure compared to placebo
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Heritage and perspectives POMC and its derivatives have been discovered over nearly a century: alpha-MSH identification by Harris in the 1950s, POMC characterization by Nakanishi and Numa (Nature, 1979), cloning of the five MC1R-MC5R receptors between 1992 and 1994 (Cone, Mountjoy, Gantz teams)
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