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These included 51,691 participants treated with SGLT2-Is, 39,609 were treated with GLP1-RAs, 70,541 were treated with DPP4-Is, and 126,238 participants treated with active comparators
Guidance advises switching to a non-oral method or adding barrier protection for four weeks after each dose escalation
A contribution of NTS astrocytes to the appetite suppression caused by acute GLP-1R agonists also seems possible from evidence showing (1) expression of GLP-1Rs in this cell type, (2) functional responses of astrocytes to exendin-4 and liraglutide, and (3) negation of appetite suppression from administration of exendin-4 into the NTS when astrocyte metabolism is selectively inhibited in this region [56]
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