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General recommendations are for 2.4 micrograms (mcg) a day, although those who are elderly or breastfeeding women may need more

Populations of particular concern based on mechanism and the absence of human data include: individuals with active or suspected malignancy (pro-angiogenic preclinical profile)

B1 Health Benefits - Contributes to energy production - Rich in anti-aging properties - Reduces Alzheimer's diseases - Maintains a healthy heart - Improves memory and appetite - Prevents cataracts - Aids in the production of red blood cells B2 Health Benefits - Contributes to energy production - Enables the body to use oxygen - Boosts immune system - Helps fight Alzheimers memory loss - Prevents muscle cramps - Treating certain types of anemia B3 Health Benefits - Contributes to energy production - Creates various sex and stress related hormones located in the adrenal glands - Maintains healthy skin - Protects against pollutants - Promotes relaxation B6 Health Benefits - Aids in maintaining healthy hormone levels - Bolsters immune system - Maintains healthy skin - Protects the heart - Aids proper nervous system functioning *Product contains benzyl alcohol as an inactive ingredient Contraindications for Benzyl Alcohol This preparation is not advised in patients who are sensitive to cobalt and/or vitamin B12

According to the results from in vitro and in vivo studies, tanshinone IIA pretreatment protects the liver from APAP-induced liver injury by activating Nrf2 and increasing the mRNA and protein levels of the Nrf2 target genes glutamate-cysteine ligase catalytic subunit (GCLC), NQO1, and HO-1 (Wang et al., 2016)