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Put plainly, the off period is not there because the compound stops working it is there because no one can point to human data showing that running it indefinitely is safe, and a scheduled break is the honest way to respect that gap

The clinical team uses baseline and follow-up labs to confirm the protocol is doing what it should and to adjust it, rather than prescribing once and walking away

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Muscle and Fat (Insulin Sensitivity): GLP-1 RAs enhance glucose uptake in muscle and adipose tissue via the PI3K/Akt pathway, improving overall insulin sensitivity (Zheng et al., 2024)