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For long-term storage beyond one year, or for vials from a multi-month supply that will not be opened for extended periods, the freezer at -20 degrees Celsius is the better choice, extending stability to two years or more
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The cycling protocols commonly recommended are partly based on this theoretical concern, though actual tolerance development has not been documented
The activation of VEGFR2-Akt-eNOS and Src-Caveolin-1-eNOS signaling pathways provides unified vascular protection across organ systems
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