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It contains glycine and aspartic acid residues, along with vulnerable peptide bonds, making it susceptible to bond cleavage and hydrolysis
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Huusko JM, Tiensuu H, Haapalainen AM, Pasanen A, Tissarinen P, Karjalainen MK, et al
This structural proximity stops there: ERRs do not bind 17beta-estradiol or any other endogenous estrogen , their ligand pocket is too narrow
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