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Semaglutide (Wegovy, Ozempic, Rybelsus): risk of non-arteritic anterior ischaemic optic neuropathy (NAION)

oral formulation (Rybelsus) also available Lixisenatide (Lyxumia) once-daily injection NICE guidance for type 2 diabetes (NG28) recommends GLP-1 receptor agonists in specific circumstances: typically as a third-line option when other treatments haven't achieved adequate glycaemic control, particularly in people with a BMI 35 kg/m (adjusted for ethnicity), or for whom weight loss would benefit other obesity-related comorbidities, or for whom insulin would have significant occupational implications

This dual mechanism distinguishes it from single-pathway GLP-1 agonists

Oral semaglutide, the active ingredient in Rybelsus, utilizes a unique formulation that enhances its absorption in the gastrointestinal tract