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Nrf2 is a transcriptional regulator of cellular homeostasis and has been reported to play a protective role against infection, as well as in the antioxidant stress response ( SLPI , since antioxidant response element (ARE) is present in the promoter region of the SLPI gene ( SLPI expression during MAC infection is attenuated in Nrf2-deficient mice

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This coordinated gene expression program regulates critical biological processes, including immune cell activation, inflammatory responses, and cellular survival (Lin et al., 2017)