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In summary, this manuscript assesses the current methods of measuring LPL activity and makes new recommendations for measuring LPL-mediated hydrolysis in pre-clinical and clinical samples
These effects typically resolve within hours and decrease with continued use as skin adapts
Therefore, before fully endorsing the use of other GLP-1 RAs in HFpEF or HFrEF, results from dedicated HF trials are needed [63]
In the pancreas, activation stimulates glucose-dependent insulin secretion, meaning insulin is released only when blood glucose levels are elevated, which reduces the risk of hypoglycemia compared to some other diabetes medications
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