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Knockdown of LONP1 in alveolar type 2 (AT2) cells induces the expression of senescence-associated secretory phenotype factors [i.e., plasminogen activator inhibitor-1 (PAI-1) and transforming growth factor- (TGF-)], as well as senescence markers (such as p53 and p21), and leads to G2 phase cell cycle arrest [71]

In clinical trials of semaglutide injection for T2DM (Ozempic), hypoglycemia was increased when semaglutide was used in combination with a sulfonylurea