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In a Mayo Clinic study presented at an annual meeting of the Endocrine Society in July 2025, researchers found that, over 18 months, 40 postmenopausal women who combined the GLP-1 drug tirzepatide (used in Mounjaro and Zepbound) with hormone therapy lost an average of 17 percent of their body weight
Slowed gastric emptying reverses
Some users report subtle increases in energy levels, reduced appetite, or slight improvements in how clothing fits during this initial phase
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