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Oxidative stress can lead to the accumulation of melanin and the formation of age spots, dullness, and uneven texture
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Is iron, B12, folate, or another nutritional deficiency documented
The accumulation of NADH leads to a reduction in the coenzyme Q pool, and coupled with the malateaspartate shuttle, a surplus of fumarate accumulates and is then converted to succinate by the reverse catalysis of succinate dehydrogenase (SDH) [73, 74]
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