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Mitochondrial GR is essential for: Protecting the electron transport chain components from oxidative damage Maintaining mitochondrial DNA integrity against oxidative lesions Supporting ATP production by preserving mitochondrial membrane potential Preventing mitochondrial-initiated apoptosis triggered by excessive oxidative stress Facilitating mitochondrial glutathione transport and utilization The mitochondrial glutathione system is particularly critical in neurons and other cells with high energy demands, where mitochondrial dysfunction can have catastrophic consequences

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The increase in histone acetylation by means of the KGcarnitine axis promoted HR-mediated DNA repair through site-specific histone acetylation

(6) Growth Hormone Deficiency in Adults Evidence shows that growth hormone deficiency in adults can be harmful