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The compounded semaglutide pill is an extremely logical new product offering given the existing platform within weight loss and expected demand from available oral GLP-1s
However, clinical trials in chronic heart failure with reduced ejection fraction (HFrEF), such as the LIVE trial, have yielded mixed or modestly negative results
Although this study was not designed to examine a dose-response relationship between the exposure and the outcome, this finding may indicate a dose-dependent effect
Despite these limitations, the findings add to the growing list of conditions that GLP-1 RAs could potentially address
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