This dual-action, once-weekly injection affects both the GLP-1 and GIP hormones
Firstly, exogenous and endogenous GLP-1 is rapidly inactivated in vivo by dipeptidyl peptidase 4 (DPP-4), which recognizes Ala or Pro at the second position of the amino acid sequence of a peptide and removes dipeptides from the N-terminus [5-7]
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Based on these data, we selected seven immunomodulatory drug classes, bestatin, imatinib, roflumilast, palacaparib, thalidomide/pomalidomide (IMiD) 41 , semaglutide, and aspirin for further evaluation