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This implies that GLP-1R is required for the control of heart rate in mice in the absence of pathology, but endogenous cardiomyocyte GLP-1R activity is not required for both adaptive responses to ischemic or cardiomyopathic injury and GLP-1 analogue-induced cardioprotection or enhanced chronotropic activity
Eriksson, S., Prigge, J
In the landmark SURMOUNT-1 trial, published in the New England Journal of Medicine, participants taking 15mg of tirzepatide lost an average of 20.9% of their body weight over 72 weeks
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